Atadja, P. W.: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

Don't use scam websites

1

Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges

Journal:

Year:

2009

Language:

english

File:

PDF, 287 KB

english, 2009

2

Activity of deacetylase inhibitor panobinostat (LBH589) in cutaneous T-cell lymphoma models: Defining molecular mechanisms of resistance

Wenlin Shao, Joseph D. Growney, Yun Feng, Gregory O'Connor, Minying Pu, Wenjing Zhu, Yung-Mae Yao, Paul Kwon, Stephen Fawell, Peter Atadja

Journal:

International Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 567 KB

english, 2010

3

Antitumor activities and on-target toxicities mediated by a TRAIL receptor agonist following cotreatment with panobinostat

Ben P. Martin, Ailsa J. Frew, Michael Bots, Stephen Fox, Fenella Long, Kazuyoshi Takeda, Hideo Yagita, Peter Atadja, Mark J. Smyth, Ricky W. Johnstone

Journal:

International Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 716 KB

english, 2011

4

Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

Lewis Whitehead, Markus R. Dobler, Branko Radetich, Yanyi Zhu, Peter W. Atadja, Tavina Claiborne, Jonathan E. Grob, Andrew McRiner, Margaret R. Pancost, Anup Patnaik, Wenlin Shao, Michael Shultz, Rite

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.54 MB

english, 2011

5

The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines

Michael B Prystowsky, Alfred Adomako, Richard V Smith, Nicole Kawachi, Wendy McKimpson, Peter Atadja, Quan Chen, Nicolas F Schlecht, Joanna L Parish, Geoffrey Childs, Thomas J Belbin

Journal:

The Journal of Pathology

Year:

2009

Language:

english

File:

PDF, 367 KB

english, 2009

6

The synergy of panobinostat plus doxorubicin in acute myeloid leukemia suggests a role for HDAC inhibitors in the control of DNA repair

Maiso, P, Colado, E, Ocio, E M, Garayoa, M, Martín, J, Atadja, P, Pandiella, A, San-Miguel, J F

Journal:

Year:

2009

Language:

english

File:

PDF, 545 KB

english, 2009

7

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

Villagra, Alejandro, Cheng, Fengdong, Wang, Hong-Wei, Suarez, Ildelfonso, Glozak, Michelle, Maurin, Michelle, Nguyen, Danny, Wright, Kenneth L, Atadja, Peter W, Bhalla, Kapil

Journal:

Nature Immunology

Year:

2008

Language:

english

File:

PDF, 521 KB

english, 2008

8

Erratum: The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

Villagra, Alejandro, Cheng, Fengdong, Wang, Hong-Wei, Suarez, Ildelfonso, Glozak, Michelle, Maurin, Michelle, Nguyen, Danny, Wright, Kenneth L, Atadja, Peter W, Bhalla, Kapil

Journal:

Nature Immunology

Year:

2009

Language:

english

File:

PDF, 81 KB

english, 2009

9

Histone deacetylase inhibitor NVP-LAQ824 has significant activity against myeloid leukemia cells in vitro and in vivo

Weisberg, E, Catley, L, Kujawa, J, Atadja, P, Remiszewski, S, Fuerst, P, Cavazza, C, Anderson, K, Griffin, J D

Journal:

Year:

2004

Language:

english

File:

PDF, 278 KB

english, 2004

10

PSC-833, a frontier in modulation of P-glycoprotein mediated multidrug resistance

Peter Atadja, Toru Watanabe, Hong Xu, Dalia Cohen

Journal:

Cancer and Metastasis Reviews

Year:

1998

File:

PDF, 434 KB

1998

11

Differential effects of transforming growth factor-β1 on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in young and old human fibroblasts

Dylan R. Edwards, Kevin J. Leco, Paul P. Beaudry, Peter W. Atadja, Claude Veillette, Karl T. Riabowol

Journal:

Experimental Gerontology

Year:

1996

Language:

english

File:

PDF, 1.35 MB

english, 1996

12

Detecting S-adenosyl-l-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay

Ying Lin, Hong Fan, Mathias Frederiksen, Kehao Zhao, Lei Jiang, Zhaofu Wang, Shaolian Zhou, Weihui Guo, Jun Gao, Shu Li, Edmund Harrington, Peter Meier, Clemens Scheufler, Yao-Chang Xu, Peter Atadja,

Journal:

Analytical Biochemistry

Year:

2012

Language:

english

File:

PDF, 916 KB

english, 2012

13

In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors

Angela Brieger, Simone Boehrer, Simone Schaaf, Daniel Nowak, Martin Ruthardt, Soo-Zin Kim, Peter Atadja, Dieter Hoelzer, Paris S Mitrou, Eckhart Weidmann, Kai Uwe Chow

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 427 KB

english, 2004

14

Induction of cell cycle arrest and DNA damage by the HDAC inhibitor panobinostat (LBH589) and the lipid peroxidation end product 4-hydroxynonenal in prostate cancer cells

Piergiorgio Pettazzoni, Stefania Pizzimenti, Cristina Toaldo, Paula Sotomayor, Luigina Tagliavacca, Song Liu, Dan Wang, Rosalba Minelli, Leigh Ellis, Peter Atadja, Eric Ciamporcero, Mario Umberto Dian

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 1.52 MB

english, 2011

15

Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma

Martin Kaiser, Britta Lamottke, Maren Mieth, Michael R. Jensen, Cornelia Quadt, Carlos Garcia-Echeverria, Peter Atadja, Ulrike Heider, Ivana Von Metzler, Seval Türkmen, Orhan Sezer

Journal:

European Journal of Haematology

Year:

2010

Language:

english

File:

PDF, 278 KB

english, 2010

16

Overexpression of Cyclin D1 Blocks Proliferation of Normal Diploid Fibroblasts

Peter Atadja, Howard Wong, Claude Veillete, Karl Riabowol

Journal:

Experimental Cell Research

Year:

1995

File:

PDF, 1.22 MB

1995

17

Epigenetic modulation of radiation response in human cancer cells with activated EGFR or HER-2 signaling: Potential role of histone deacetylase 6

In Ah Kim, Mina No, Jang Mi Lee, Jin Hee Shin, Jee Sun Oh, Eun Jung Choi, Il Han Kim, Peter Atadja, Eric J. Bernhard

Journal:

Radiotherapy and Oncology

Year:

2009

Language:

english

File:

PDF, 710 KB

english, 2009

18

193 Histone deacetylase inhibitors LAQ824 and LBH589 inhibit proliferation and modulate angiogenesis-related genes in human endothelial cells

D. Qian, P. Atadja, R. Pili

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 146 KB

english, 2004

19

251 Histone deacetylase inhibition — a promising anticancer therapeutic strategy

P. Atadja, M. Hsu, P. Kwon, R. Pili, K. Bhalla, A. Wood

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 141 KB

english, 2004

20

584 POSTER Histone deacetylase inhibitors abrogate the levels and activity of estrogen receptor (ER) α and histone deacetylase (HDAC) 6 in human breast cancer cells (BCCs)

W. Fiskus, A. Mohapatra, P. Bali, M. Balasis, R. Rao, P. Atadja, J. Wu, K. Bhalla

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 60 KB

english, 2006

21

702 POSTER Phase I pharmacokinetic and pharmacodynamic study of once-weekly IV LBH589

S. Sharma, N.J. Vogelzang, J. Beck, A. Patnaik, M. Mita, M. Dugan, A. Hwang, K. Culver, P. Atadja, H.M. Prince

Journal:

European Journal of Cancer Supplements

Year:

2007

Language:

english

File:

PDF, 81 KB

english, 2007

22

701 POSTER Phase I study of oral LBH589 in advanced solid tumours and non-Hodgkin's lymphoma

H.M. Prince, D. George, A. Patnick, M. Mita, P. Atadja, M. Dugan, D. Butterfoss, K. Culver, H.S. Burris, J. Beck

Journal:

European Journal of Cancer Supplements

Year:

2007

Language:

english

File:

PDF, 58 KB

english, 2007

23

151 POSTER Efficacy of panobinostat (LBH589) in lung cancer: potent anticancer activity in both in vitro and in vivo tumor models

P. Atadja, W. Shao, Y. Wang, J. Growney, Y. Feng, Y.M. Yao, A. Wallace, C. Crisanti, S. Fawell, S. Albelda

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 69 KB

english, 2008

24

161 POSTER Potent anticancer activity of panobinostat (LBH589) in models of hormone-refractory prostate cancer (HRPC): targeting the androgen receptor

W. Shao, J. Growney, G. O'Connor, Y. Feng, H. Scher, Y.M. Yao, S. Fawell, P. Atadja

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 58 KB

english, 2008

25

Biocatalytic Synthesis and Structure Elucidation of Cyclized Metabolites of the Deacetylase Inhibitor Panobinostat (LBH589)

Fredenhagen, A., Kittelmann, M., Oberer, L., Kuhn, A., Kuhnol, J., Delemonte, T., Aichholz, R., Wang, P., Atadja, P., Shultz, M. D.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 1.42 MB

english, 2012

26

Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies

DeAngelo, D J, Spencer, A, Bhalla, K N, Prince, H M, Fischer, T, Kindler, T, Giles, F J, Scott, J W, Parker, K, Liu, A, Woo, M, Atadja, P, Mishra, K K, Ottmann, O G

Journal:

Year:

2013

Language:

english

File:

PDF, 593 KB

english, 2013

27

Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of a Novel Histone Deacetylase Inhibitor, LAQ824, in Human Colon Carcinoma Cells and Xenografts

Chung, Yuen-Li, Troy, Helen, Kristeleit, Rebecca, Aherne, Wynne, Jackson, L. Elizabeth, Atadja, Peter, Griffiths, John R., Judson, Ian R., Workman, Paul, Leach, Martin O., Beloueche-Babari, Mounia

Journal:

Year:

2008

Language:

english

File:

PDF, 624 KB

english, 2008

28

7054 POSTER Concurrent Histone Deacetylase and Mammalian Target of Rapamycin Inhibition Attenuate Androgen Receptor and Hypoxia Signaling Associated With Alterations in MicroRNA Expression

Ellis, L., Lehet, K., Ramakrishnan, S., Miles, K.M., Wang, D., Liu, S., Atadja, P., Carducci, M.A., Pili, R.

Journal:

European Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 44 KB

english, 2011

29

Epigenetics in cancer: Targeting chromatin modifications

Ellis, L., Atadja, P. W., Johnstone, R. W.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 329 KB

english, 2009

30

Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia

Cao, Fang, Townsend, Elizabeth C., Karatas, Hacer, Xu, Jing, Li, Li, Lee, Shirley, Liu, Liu, Chen, Yong, Ouillette, Peter, Zhu, Jidong, Hess, Jay L., Atadja, Peter, Lei, Ming, Qin, Zhaohui S., Malek,

Journal:

Year:

2014

Language:

english

File:

PDF, 3.55 MB

english, 2014

31

Histone Deacetylase Inhibitor Panobinostat Induces Clinical Responses with Associated Alterations in Gene Expression Profiles in Cutaneous T-Cell Lymphoma

Ellis, L., Pan, Y., Smyth, G. K., George, D. J., McCormack, C., Williams-Truax, R., Mita, M., Beck, J., Burris, H., Ryan, G., Atadja, P., Butterfoss, D., Dugan, M., Culver, K., Johnstone, R. W., Princ

Journal:

Clinical Cancer Research

Year:

2008

Language:

english

File:

PDF, 949 KB

english, 2008

32

Inhibitors of Human Histone Deacetylase: Synthesis and Enzyme and Cellular Activity of Straight Chain Hydroxamates

Remiszewski, Stacy W., Sambucetti, Lidia C., Atadja, Peter, Bair, Kenneth W., Cornell, Wendy D., Green, Michael A., Howell, Kobporn Lulu, Jung, Manfred, Kwon, Paul, Trogani, Nancy, Walker, Heather

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 242 KB

english, 2002

33

Absolute Quantification of Histone PTM Marks by MRM-Based LC-MS/MS

Gao, Jun, Liao, Rijing, Yu, Yanyan, Zhai, Huili, Wang, Yingqi, Sack, Ragna, Peters, Antoine H. F. M., Chen, Jiajia, Wu, Haiping, Huang, Zheng, Hu, Min, Qi, Wei, Lu, Chris, Atadja, Peter, Oyang, Counde

Journal:

Analytical Chemistry

Year:

2014

Language:

english

File:

PDF, 1.64 MB

english, 2014

34

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors

Bots, M., Verbrugge, I., Martin, B. P., Salmon, J. M., Ghisi, M., Baker, A., Stanley, K., Shortt, J., Ossenkoppele, G. J., Zuber, J., Rappaport, A. R., Atadja, P., Lowe, S. W., Johnstone, R. W.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.04 MB

english, 2014

35

Regulation of transcription factor activity during cellular aging

Wheaton, Keith, Atadja, Peter, Riabowol, Karl

Journal:

Biochemistry and Cell Biology

Year:

1996

Language:

english

File:

PDF, 1.71 MB

english, 1996

36

Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells

Fiskus, W., Pranpat, M., Balasis, M., Herger, B., Rao, R., Chinnaiyan, A., Atadja, P., Bhalla, K.

Journal:

Molecular Cancer Therapeutics

Year:

2006

Language:

english

File:

PDF, 539 KB

english, 2006

37

Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma

Matthews, G M, Lefebure, M, Doyle, M A, Shortt, J, Ellul, J, Chesi, M, Banks, K-M, Vidacs, E, Faulkner, D, Atadja, P, Bergsagel, P L, Johnstone, R W

Journal:

Cell Death and Disease

Year:

2013

Language:

english

File:

PDF, 2.23 MB

english, 2013

38

SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells

Scuto, A, Kirschbaum, M, Buettner, R, Kujawski, M, Cermak, J M, Atadja, P, Jove, R

Journal:

Cell Death and Disease

Year:

2013

Language:

english

File:

PDF, 1.79 MB

english, 2013

39

Increased Activity of p53 in Senescing Fibroblasts

Peter Atadja, Howard Wong, Igor Garkavtsev, Claude Veillette and Karl Riabowol

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.29 MB

english, 1995

40

Inhibition of Histone Deacetylases Promotes Ubiquitin-Dependent Proteasomal Degradation of DNA Methyltransferase 1 in Human Breast Cancer Cells

Zhou, Q., Agoston, A. T., Atadja, P., Nelson, W. G., Davidson, N. E.

Journal:

Molecular Cancer Research

Year:

2008

Language:

english

File:

PDF, 539 KB

english, 2008

41

Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia

Salmon, Jessica M, Bots, Michael, Vidacs, Eva, Stanley, Kym L, Atadja, Peter, Zuber, Johannes, Johnstone, Ricky W

Journal:

Clinical Epigenetics

Year:

2015

Language:

english

File:

PDF, 1.64 MB

english, 2015

42

Isolation and Characterization of a Novel Class II Histone Deacetylase, HDAC10

Fischer, D. D., Cai, R., Bhatia, U., Asselbergs, F. A. M., Song, C., Terry, R., Trogani, N., Widmer, R., Atadja, P., Cohen, D.

Journal:

Journal of Biological Chemistry

Year:

2002

Language:

english

File:

PDF, 1.46 MB

english, 2002

43

Histone Deacetylase Inhibitors Activate NF- B in Human Leukemia Cells through an ATM/NEMO-related Pathway

Rosato, R. R., Kolla, S. S., Hock, S. K., Almenara, J. A., Patel, A., Amin, S., Atadja, P., Fisher, P. B., Dent, P., Grant, S.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 3.80 MB

english, 2010

44

Epigenetic Silencing of the Tetraspanin CD9 during Disease Progression in Multiple Myeloma Cells and Correlation with Survival

De Bruyne, E., Bos, T. J., Asosingh, K., Vande Broek, I., Menu, E., Van Valckenborgh, E., Atadja, P., Coiteux, V., Leleu, X., Thielemans, K., Van Camp, B., Vanderkerken, K., Van Riet, I.

Journal:

Clinical Cancer Research

Year:

2008

Language:

english

File:

PDF, 259 KB

english, 2008

45

Histone Deacetylase (HDAC) Inhibitor LBH589 Increases Duration of -H2AX Foci and Confines HDAC4 to the Cytoplasm in Irradiated Non-Small Cell Lung Cancer

Geng, L., Cuneo, K. C., Fu, A., Tu, T., Atadja, P. W., Hallahan, D. E.

Journal:

Cancer Research

Year:

2006

Language:

english

File:

PDF, 431 KB

english, 2006

46

Structure of Human SMYD2 Protein Reveals the Basis of p53 Tumor Suppressor Methylation

Wang, L., Li, L., Zhang, H., Luo, X., Dai, J., Zhou, S., Gu, J., Zhu, J., Atadja, P., Lu, C., Li, E., Zhao, K.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 3.22 MB

english, 2011

47

Hydroxamic Acid Analogue Histone Deacetylase Inhibitors Attenuate Estrogen Receptor- Levels and Transcriptional Activity: A Result of Hyperacetylation and Inhibition of Chaperone Function of Heat Shock Protein 90

Fiskus, W., Ren, Y., Mohapatra, A., Bali, P., Mandawat, A., Rao, R., Herger, B., Yang, Y., Atadja, P., Wu, J., Bhalla, K.

Journal:

Clinical Cancer Research

Year:

2007

Language:

english

File:

PDF, 582 KB

english, 2007

48

High Efficacy of Panobinostat Towards Human Gastrointestinal Stromal Tumors in a Xenograft Mouse Model

Floris, G., Debiec-Rychter, M., Sciot, R., Stefan, C., Fieuws, S., Machiels, K., Atadja, P., Wozniak, A., Faa, G., Schoffski, P.

Journal:

Clinical Cancer Research

Year:

2009

Language:

english

File:

PDF, 771 KB

english, 2009

49

Treatment with Panobinostat Induces Glucose-Regulated Protein 78 Acetylation and Endoplasmic Reticulum Stress in Breast Cancer Cells

Rao, R., Nalluri, S., Kolhe, R., Yang, Y., Fiskus, W., Chen, J., Ha, K., Buckley, K. M., Balusu, R., Coothankandaswamy, V., Joshi, A., Atadja, P., Bhalla, K. N.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 941 KB

english, 2010

50

The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity

Woods, David M., Woan, Karrune, Cheng, Fengdong, Wang, Hongwei, Perez-Villarroel, Patricio, Lee, Calvin, Lienlaf, Maritza, Atadja, Peter, Seto, Edward, Weber, Jeffrey, Sotomayor, Eduardo M., Villagra,

Journal:

Melanoma Research

Year:

2013

Language:

english

File:

PDF, 614 KB

english, 2013